Advantix Antiparasitic for Dogs

Features:
- Kills and Repels ticks reducing the risk of transmission of diseases such as boreliosis, rickettosis, ehrlichiosis.
- Kills fleas on the dog.
Larval forms in the environment are killed as a result of contact with the treated dog.
- Can be used as part of the treatment strategy for allergic flea dermatitis.
- Repels against mosquitoes and phlebotomes
Reduces the risk of diseases such as leishmaniasis.

Qualitative-quantitative composition:
- 1 ml of solution contains: active ingredient
- imidacloprid 100 mg
- permethrin 500 mg

Posology and method of administration:
The minimum recommended dose is 10 mg/kg body weight of imidacloprid and 50 mg/kg body weight of permethrin. Apply only to undamaged skin.
One treatment prevents tick and flea infestation for 4 weeks, thereby reducing the risk of transmission of tick-borne diseases. The product remains effective even if the animal gets wet.
For more information just consult the package insert inside the package.

Contraindications:
Do not use on puppies under 7 weeks of age.
Do not use in cats!

Please note:
the product can be used as part of a treatment strategy for allergic flea dermatitis (APD). One treatment provides significant activity against phlebotomus and mosquitoes for four weeks. Phlebotomes and mosquitoes are repelled thus reducing the risk of disease transmission (e.g., leishmaniasis).

HOW ADVANTIX WORKS

Advantix is a product resulting from the combination of two ingredients: Imidacloprid-known for its rapid action on fleas-and permethrin, a pyrethroid known for its effectiveness. The two substances, acting together, cause Imidacloprid to increase the effectiveness of permethrin.

The product providesrepellent activity against ticks, phlebotomus and mosquitoes, thus preventing the parasites from biting and thus reducing the risk of transmission of vector-borne dog diseases such as for example borreliosis, rickettsiosis, ehrlichiosis and leishmaniasis. In addition, the product provides repellent activity against the horse fly, thus aiding in the prevention of fly-bite dermatitis.

Imidacloprid is an ectoparasiticide belonging to the class of chloronicotinyl compounds.
Chemically, it can be classified as a chloronicotinylnitroguanidine. Imidacloprid is effective against adult fleas and the larval stages of fleas. In addition to the adulticidal efficacy against fleas of Imidacloprid, larvicidal efficacy has been demonstrated in the environment surrounding the treated pet.
Larval stages present in the dog's surroundings are killed following contact with a treated animal. Imidacloprid possesses a high affinity for nicotinergic receptors for acetylcholine in the postsynaptic region of the central nervous system (CNS) of insects. The resulting inhibition of cholinergic transmission leads in insects to paralysis and death of the pest.

Permethrin belongs to the class of type I pyrethroid acaricides and insecticides and also acts as a repellent. Pyrethroids affect the voltage-dependent sodium channels of vertebrates and invertebrates.
Pyrethroids are so-called "open channel blockers" and affect the sodium channel by slowing both its activation and inactivation properties, thus leading to hyperexcitability and death of the pest.